What is the role of Olprinone (OLP) in hepatoprotection after partial hepatectomy and endotoxin-induced liver injury?

Label:chem

Topic
Liver injury is a significant concern after partial hepatectomy, especially when combined with endotoxin-induced inflammation. Understanding the role of Olprinone (OLP) in mitigating such liver injury is crucial for improving post-surgical outcomes.
Answer
Olprinone (OLP) acts as a selective inhibitor of phosphodiesterase III (PDE-III), which increases intracellular cyclic adenosine monophosphate (cAMP) levels. This increase in cAMP leads to both inotropic and vasodilator effects, which can reduce inflammation and improve microcirculation. In the study, OLP significantly increased survival rates in rats subjected to 70% partial hepatectomy and lipopolysaccharide (LPS) treatment, reduced pro-inflammatory cytokine levels, and alleviated pathological liver damage.
Return to Home Chemical List
Knowledge you may be interested in
What is the role of tacrolimus in preventing acute endothelial graft rejection after penetrating keratoplasty (PKP)? How does tacrolimus perform in treating adenoviral corneal subepithelial infiltrates (SEIs)? What are the advantages of using tacrolimus over corticosteroids in ocular graft-versus-host disease (GVHD)? How effective is tacrolimus in managing dry eye secondary to Sjogren syndrome? What are the common side effects of topical tacrolimus in ocular conditions? How does tacrolimus compare to other treatments in terms of efficacy for vernal keratoconjunctivitis (VKC)? What is the role of tacrolimus in the management of ocular surface diseases? What are the potential targets of allosamidin in asthma? What is the anti-asthmatic activity of allosamidin and demethylallosamidin? How does allosamidin affect chitinase production in Streptomyces? How does Olprinone (OLP) affect survival rates in rats subjected to partial hepatectomy and LPS treatment? What is the effect of Olprinone (OLP) on pro-inflammatory cytokines and chemokines in the liver? How does Olprinone (OLP) influence inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in the liver? What histopathological changes are observed in the liver after treatment with Olprinone (OLP)? How does Olprinone (OLP) affect NF-κB activation in hepatocytes? What are the potential clinical implications of using Olprinone (OLP) for hepatoprotection? What is the role of lanreotide in the treatment of gastroenteropancreatic neuroendocrine tumors (NETs)? How does lanreotide affect T cell function and survival in vitro? What are the in vivo effects of lanreotide on T cell gene expression in NET patients? Which specific genes were differentially expressed in responders versus non-responders before lanreotide treatment?