What is the structure and biosynthesis of allosamidin?

Label:chem

Topic
Allosamidin is a secondary metabolite produced by Streptomyces species and is known for its unique pseudotrisaccharide structure. Understanding its structure and biosynthesis is crucial for exploring its biological activities and potential applications.
Answer
Allosamidin has a pseudotrisaccharide structure composed of two N-acetyl-D-allosamine moieties and one allosamizoline moiety. The biosynthesis of allosamidin involves the incorporation of D-glucosamine molecules for allosamine and the 2-aminocyclitol skeleton, while the (CH3)2N-C moiety of allosamizoline originates from a methyl group of L-methionine and a guanidino group of L-arginine. The cyclopentane ring of allosamizoline is formed through a 6-aldehyde intermediate.
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