How does Olprinone (OLP) affect survival rates in rats subjected to partial hepatectomy and LPS treatment?

Label:chem

Topic
Survival rates in animal models of severe acute liver injury are often low due to the combined effects of partial hepatectomy and endotoxin-induced inflammation.
Answer
In a study, rats treated with Olprinone (OLP) at a dose of 10 mg/kg body weight showed a significant increase in survival rates (85.7%) compared to those treated with partial hepatectomy and LPS alone (38.5%). This suggests that OLP has a protective effect against endotoxic liver injury by reducing inflammation and improving liver function.
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