How does allosamidin affect chitinase production in Streptomyces?

Label:chem

Topic
Chitinases are essential for Streptomyces to degrade chitin and obtain nutrients. Understanding how allosamidin regulates chitinase production can help in developing strategies for enhancing chitin degradation in soil.
Answer
Allosamidin enhances chitinase production in Streptomyces by acting through a two-component regulatory system. It binds to the sensor region of Chi65S, which then activates Chi65R, leading to increased expression of the chi65 gene. This results in higher production of the 46 kDa and 105 kDa chitinases. The effect is observed in various Streptomyces strains, indicating a general regulatory mechanism.
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