What are the effects of vitamin E on neuroinflammation and oxidative stress in the brain?

Label:chem

Topic
Neuroinflammation and oxidative stress are interlinked pathological processes that play a significant role in the onset and progression of numerous neurological disorders. Vitamin E, with its antioxidant properties, has been studied for its potential to reduce neuroinflammation and oxidative stress.

From: "Shifting Perspectives on the Role of Tocotrienol vs. Tocopherol in Brain Health: A Scoping Review", Int. J. Mol. Sci. 2025, 26(13), 6339;
Answer
Vitamin E, particularly tocopherols, has been shown to reduce neuroinflammation by modulating inflammatory signaling pathways and reducing the activation of microglia. It also reduces oxidative stress by scavenging reactive oxygen species (ROS) and reactive nitrogen species (RNS), thereby preventing lipid peroxidation and maintaining cellular integrity. These effects contribute to neuroprotection and may delay the progression of neurodegenerative diseases.
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