What is the potential of boronic acid derivatization and activity in agrochemical discovery?

Label:chem

Topic
Since the approval of Bortezomib (Velcade®) by the U.S. Food and Drug Administration (FDA) in 2003, boron-containing drugs have successfully entered the global market, spanning therapeutic areas such as anticancer, antibacterial, and antifungal agents. Meanwhile, boron is an essential trace element for plant growth, and boronic acid has been widely used as plant resistance inducers and growth promoters. In 2024, the Fungicide Resistance Action Committee (FRAC) introduced benzoxaboroles as a new category of fungicides, demonstrating the significant application potential of boron-containing compounds (BCCs) in the field of agricultural fungicides.

From: "Potential of Boronic Acid Derivatization and Activity in Agrochemical Discovery", Molecules 2025, 30(14), 3018;
Answer
Boronic acid derivatization holds significant potential in agrochemical discovery. It can be used to develop new pesticides with multiple targets and high selectivity, potentially breaking through the resistance bottleneck of traditional building blocks. Boronic acids and their derivatives can act as effective fungicides, insecticides, and growth regulators in agriculture, targeting key enzymes and pathways in pathogens and plants.
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