How does Acetobacter ghanensis JN01 biodegrade acetaldehyde?

Label:chem

Topic
Acetaldehyde is a highly reactive and toxic compound that can cause DNA adducts, induce oxidative stress, and impair mitochondrial function. It is a primary metabolite of ethanol metabolism and is classified as a Group 1 carcinogen.

From: "Biodegradation of Both Ethanol and Acetaldehyde by Acetobacter ghanensis JN01", Catalysts 2025, 15(8), 756;
Answer
Acetobacter ghanensis JN01 biodegrades acetaldehyde by converting it to acetate through the action of aldehyde dehydrogenase (ALDH). The acetate can then be further metabolized into acetyl-CoA and fed into the TCA cycle. This efficient conversion prevents the accumulation of toxic acetaldehyde, reducing its harmful effects.
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