What is the role of alteplase in the treatment of acute ischemic stroke (AIS)?

Label:chem

Topic
Alteplase is a thrombolytic agent used to dissolve blood clots and restore blood flow in patients with AIS. It is a standard treatment for AIS within 4.5 hours of symptom onset.

From: "Drug repurposing of argatroban, glimepiride and ranolazine shows anti-SARS-CoV-2 activity via diverse mechanisms", Heliyon, Volume 11, Issue 3, 15 February 2025, e41894
Answer
Alteplase is used to achieve vessel recanalization in patients with AIS, improving functional outcomes by restoring blood flow to ischemic brain tissue. The study evaluates the efficacy of combining alteplase with argatroban to further enhance these outcomes.
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