How does dual antiplatelet therapy (DAPT) contribute to the management of early neurological deterioration (END) following stroke?

Label:chem

Topic
Dual antiplatelet therapy (DAPT) typically includes the use of aspirin and clopidogrel, which work by inhibiting platelet aggregation and preventing thrombus formation. This therapy is commonly used in clinical practice to manage early neurological deterioration (END) following stroke.

From: "Argatroban plus dual antiplatelet therapy: Preliminary evidence for managing early neurological deterioration after lacunar stroke", Clinical Neurology and Neurosurgery, Volume 250, March 2025, 108786
Answer
DAPT alone significantly reduces NIHSS scores and improves functional outcomes in patients with END following stroke. However, the combination of Argatroban with DAPT provides superior efficacy in reducing NIHSS scores and improving long-term functional outcomes (mRS scores) compared to DAPT alone, without increasing the risk of serious bleeding complications.
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