What is the role of argatroban in inhibiting SARS-CoV-2?

Label:chem

Topic
Argatroban is an anticoagulant that acts through competitive and selective inhibition of thrombin. It is used for the prevention and treatment of heparin-induced thrombocytopenia and other thrombotic conditions. This study investigates its potential repurposing for inhibiting SARS-CoV-2 entry into host cells by targeting the ACE2 receptor.

From: "Drug repurposing of argatroban, glimepiride and ranolazine shows anti-SARS-CoV-2 activity via diverse mechanisms", Heliyon, Volume 11, Issue 3, 15 February 2025, e41894
Answer
Argatroban shows potential antiviral activity against SARS-CoV-2 by primarily inducing a direct virucidal effect and to a lesser extent by inhibiting viral adsorption and replication. It has an IC50 of 20 μM and a CC50 of 1900 μM, with a selectivity index of 95, indicating its relative safety and potential as a therapeutic agent.
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