How can the stability of boronic acid compounds be improved for agricultural applications?

Label:chem

Topic
Boronic acid compounds are prone to degradation, which can limit their effectiveness in agricultural applications.

From: "Potential of Boronic Acid Derivatization and Activity in Agrochemical Discovery", Molecules 2025, 30(14), 3018;
Answer
The stability of boronic acid compounds can be improved by converting them into more stable forms such as boronate esters or benzoxaboroles. For example, benzoxaboroles are more stable than boronic acids and phenylboronic acids due to their internal ester structure, which provides higher resistance to hydrolysis. Additionally, protective groups like MIDA (N-methyliminodiacetic acid) can be used to mask boronic acid functionalities, enhancing their stability and water solubility.
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