How does Acetobacter ghanensis JN01 biodegrade ethanol?

Label:chem

Topic
Ethanol is primarily metabolized in the liver through a two-step enzymatic process involving alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), producing acetaldehyde as a key intermediate. Acetaldehyde is highly toxic and classified as a Group 1 carcinogen.

From: "Biodegradation of Both Ethanol and Acetaldehyde by Acetobacter ghanensis JN01", Catalysts 2025, 15(8), 756;
Answer
Acetobacter ghanensis JN01 biodegrades ethanol by oxidizing it to acetaldehyde using alcohol dehydrogenase (ADH), and then converting acetaldehyde to acetate using aldehyde dehydrogenase (ALDH). The resulting acetate can be further converted to acetyl-CoA and fed into the tricarboxylic acid (TCA) cycle. This process prevents the accumulation of toxic acetaldehyde.
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