How does BD11 affect the virulence traits of Candida albicans?

Label:chem

Topic
Candida albicans is an opportunistic fungal pathogen that utilizes various virulence factors, such as filamentation and biofilm formation, to infect the host.

From: "Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism", Journal of Advanced Research, 28 July 2025
Answer
BD11 significantly inhibits the filamentation and biofilm formation of Candida albicans. It reduces the intracellular ATP levels and downregulates key genes in the Ras1/cAMP/PKA signaling pathway, which are crucial for hyphal formation. This inhibition of key virulence traits reduces the pathogenicity of Candida albicans.
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