What is the role of BD11 in inhibiting the growth of Candida albicans?

Label:chem

Topic
BD11 is a boronic acid derivative identified as a potent antifungal candidate. It has shown strong antifungal activity against various pathogenic fungi, including Candida albicans, with low cytotoxicity and minimal propensity to induce drug resistance.

From: "Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism", Journal of Advanced Research, 28 July 2025
Answer
BD11 inhibits the growth of Candida albicans by compromising its energy metabolism. It impairs mitochondrial function, reduces succinate dehydrogenase (SDH) activity, decreases intracellular ATP levels, and disrupts cell wall integrity. These effects collectively inhibit fungal growth and virulence, making BD11 a promising candidate for treating fungal infections.
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