What is the role of ranolazine in inhibiting SARS-CoV-2?

Label:chem

Topic
Ranolazine is an antianginal drug with antiarrhythmic properties used for managing chronic angina and arrhythmias. This study explores its potential antiviral activity against SARS-CoV-2 by targeting the ACE2 receptor.

From: "Drug repurposing of argatroban, glimepiride and ranolazine shows anti-SARS-CoV-2 activity via diverse mechanisms", Heliyon, Volume 11, Issue 3, 15 February 2025, e41894
Answer
Ranolazine exerts its antiviral impact mainly by inhibiting viral adsorption and to a lesser extent through a direct virucidal mechanism. It has an IC50 of 300 μM and a CC50 of 3000 μM, with a selectivity index of 10, indicating its relative safety and potential as a therapeutic agent.
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