What is the role of glimepiride in inhibiting SARS-CoV-2?

Label:chem

Topic
Glimepiride is an anti-diabetic drug that has been suggested to potentially target SARS-CoV-2 Mpro, a viral protease crucial for polyprotein processing. This study evaluates its ability to inhibit SARS-CoV-2 by targeting the ACE2 receptor.

From: "Drug repurposing of argatroban, glimepiride and ranolazine shows anti-SARS-CoV-2 activity via diverse mechanisms", Heliyon, Volume 11, Issue 3, 15 February 2025, e41894
Answer
Glimepiride inhibits SARS-CoV-2 primarily by inhibiting intracellular viral replication and to a lesser extent by inhibiting viral adsorption. It has an IC50 of 47 μM and a CC50 of 2860 μM, with a selectivity index of 61, indicating its relative safety and potential as a therapeutic agent.
Return to Home Chemical List
Knowledge you may be interested in
What is the role of argatroban in inhibiting SARS-CoV-2? What are the safety profiles of Argatroban and DAPT when used together for managing early neurological deterioration (END) following stroke? How does dual antiplatelet therapy (DAPT) contribute to the management of early neurological deterioration (END) following stroke? What is the role of Argatroban in managing early neurological deterioration (END) following stroke? What are the main phenolic compounds identified in HBWG and HBVN that contribute to the inhibition of pyrraline formation? What is the role of phenolic compounds from highland barley whole grain (HBWG) and highland barley vinasse (HBVN) in inhibiting pyrraline formation? What is the effect of pyrraline modification on the potential allergenicity of ovalbumin (OVA) in mice? How does pyrraline modification affect the CD4+ T-cell immunogenicity of ovalbumin (OVA)? What is the role of scavenger receptor class A (SR-A) in the uptake of pyrraline-modified ovalbumin (Pyr-OVA) by dendritic cells (DCs)? How does the Maillard reaction product pyrraline enhance the allergenicity of ovalbumin (OVA)? What is the role of ranolazine in inhibiting SARS-CoV-2? What is the role of argatroban in the treatment of acute ischemic stroke (AIS)? What is the role of alteplase in the treatment of acute ischemic stroke (AIS)? What is the role of BD11 in inhibiting the growth of Candida albicans? How does BD11 affect the virulence traits of Candida albicans? What is the potential of boronic acid derivatization and activity in agrochemical discovery? How do boronic acids and their derivatives function as fungicides in agriculture? How can the stability of boronic acid compounds be improved for agricultural applications? How does nitrogen supplementation during fermentation influence yeast viability and acetaldehyde production in the post-fermentation phase of wine? How do different cooling rates after fermentation affect yeast viability and acetaldehyde production in wine?