How does hcast 3-25 interact with calpain-1 in the absence of Ca2+?

Label:chem

Topic
Calpastatin is known to interact with calpain-1 in the presence of Ca2+, leading to the inhibition of calpain-1 activity. However, the study explores whether hcast 3-25, which lacks the inhibitory domains, can still interact with calpain-1 in the absence of Ca2+.
Answer
hcast 3-25 can interact with calpain-1 in the absence of Ca2+. This interaction is Ca2+-independent and occurs when calpain-1 is in its native inactive conformation. The study demonstrates that hcast 3-25 binds to calpain-1 and protects it from degradation by activated calpain-1 molecules, even in the absence of Ca2+. This interaction is crucial for maintaining the catalytic activity of calpain-1.
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