How does calpastatin overexpression affect podocyte autophagy and kidney injury in the context of Angiotensin II-induced hypertension?

Label:chem

Topic
Calpastatin is a specific inhibitor of calpains, proteases that can disrupt autophagy. In hypertension-induced kidney injury, Angiotensin II activates calpains, leading to autophagy inhibition and podocyte damage.
Answer
Calpastatin overexpression in podocytes prevents Angiotensin II-induced autophagy inhibition and podocyte injury. This is achieved by reducing calpain activity, thereby maintaining autophagy flux. Calpastatin overexpression also limits albuminuria and glomerulosclerosis, highlighting its protective role in hypertension-associated nephropathies.
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