What is the mechanism by which Angiotensin II inhibits autophagy in podocytes?

Label:chem

Topic
Angiotensin II (AngII) is known to promote podocyte injury through various mechanisms, including the activation of the renin-angiotensin system (RAS). Recent studies have shown that AngII can also affect cellular processes such as autophagy, which is crucial for maintaining podocyte health.
Answer
Angiotensin II inhibits autophagy in podocytes through the activation of calpains. Calpains are calcium-dependent proteases that can cleave autophagy-related proteins, thereby blocking autophagy flux. This inhibition of autophagy contributes to podocyte injury and glomerulosclerosis in hypertension-induced kidney disease.
Return to Home Chemical List
Knowledge you may be interested in
How does the deletion of Atg5 in podocytes affect the progression of Angiotensin II-induced kidney injury? What is the role of calpastatin in preventing Angiotensin II-mediated podocyte injury? How does Angiotensin II (AngII) affect podocyte autophagy in hypertension-induced kidney injury? What is the effect of hcast 3-25 on calpain-1 activity in the presence of inhibitory calpastatins? How does hcast 3-25 interact with calpain-1 in the absence of Ca2+? What is the role of hcast 3-25 in the regulation of calpain-1 activity? What are the implications of acute kidney injury (AKI) on the treatment effect of milrinone compared to dobutamine? How does renal function impact the efficacy of milrinone compared to dobutamine in cardiogenic shock? What is the role of dobutamine in the management of cardiogenic shock? What is the role of milrinone in the management of cardiogenic shock? How does calpastatin overexpression affect podocyte autophagy and kidney injury in the context of Angiotensin II-induced hypertension? What are the synthetic routes explored for the preparation of crinamic acid and its derivatives, and what is the significance of these compounds in biological activity? How does the presence of L-Arginine affect the synthesis and properties of Ag/AgCl nanoparticles when using sugar ligands? How does the presence of chloride ions affect the interaction between L-Arginine and silver ions during the synthesis of Ag/AgCl nanoparticles? What is the antibacterial activity of Ag/AgCl nanoparticles synthesized with different sugar ligands against multidrug-resistant Escherichia coli? What is the role of silver/silver chloride (Ag/AgCl) quasi-reference electrodes (QREs) in electrochemical measurements under gamma radiation for corrosion studies? How does gamma radiation affect the stability of Ag/AgCl quasi-reference electrodes (QREs)? What is the significance of the AgCl coating on the stability of Ag/AgCl quasi-reference electrodes (QREs) under gamma radiation? How does gamma radiation affect the corrosion behavior of copper in the presence of Ag/AgCl quasi-reference electrodes (QREs)? What is the role of GilR in the biosynthesis of gilvocarcin V?