What role does tetrahydrocannabinol (THC) play in the development of Takotsubo cardiomyopathy (TTC)?

Label:chem

Topic
Tetrahydrocannabinol (THC) is the primary psychoactive component of cannabis. It interacts with the endocannabinoid system, which includes the CB1 and CB2 receptors. THC can mediate cardiovascular effects through activation of the sympathetic nervous system and inhibition of the parasympathetic nervous system, leading to a hyperadrenergic state. This can potentially trigger TTC, a condition characterized by transient left ventricular dysfunction in the absence of obstructive coronary disease.
Answer
THC may precipitate a catecholamine surge, leading to TTC in susceptible individuals. In this case, the patient's chronic cannabis use and pre-existing comorbidities likely contributed to the development of TTC, which presented with cardiogenic shock and ventricular tachycardia.
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