What is the effect of hcast 3-25 on calpain-1 activity in the presence of inhibitory calpastatins?

Label:chem

Topic
The study investigates how hcast 3-25 affects calpain-1 activity when inhibitory calpastatins, such as cast600, are present. It explores whether hcast 3-25 interferes with the inhibitory function of calpastatins or enhances the activity of calpain-1.
Answer
hcast 3-25 does not interfere with the inhibitory activity of calpastatins but enhances the activity of calpain-1. When hcast 3-25 is present with calpain-1 and inhibitory calpastatins (e.g., cast600), it protects calpain-1 from degradation, allowing the inhibitory calpastatins to effectively regulate calpain-1 activity. The study concludes that hcast 3-25 is essential for maintaining the appropriate amount of active calpain-1 molecules that can be modulated by inhibitory calpastatins.
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