What is the role of Milrinone in treating severe refractory cerebral vasospasm (VSP) following aneurysmal subarachnoid hemorrhage (aSAH)?

Label:chem

Topic
Milrinone is a phosphodiesterase III inhibitor with vasodilating, positive inotropic, and anti-inflammatory effects. It has been used in cardiology for heart failure and has been investigated for its potential to prevent cerebral vasospasm in both animal and human studies. In this study, Milrinone is used intraarterially (ia) as a rescue therapy for patients with refractory VSP.
Answer
Milrinone is used to improve vessel diameter and reduce vasospasm in patients with severe refractory VSP following aSAH. It is administered intraarterially in combination with Nimodipine to enhance vasodilation and improve clinical outcomes.
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