What is the role of calpastatin in preventing Angiotensin II-mediated podocyte injury?

Label:chem

Topic
Calpastatin is an endogenous inhibitor of calpains, a family of calcium-dependent proteases. Calpains have been implicated in various cellular processes, including autophagy regulation. In the context of Angiotensin II (AngII)-induced hypertension, calpains are activated and contribute to podocyte injury by inhibiting autophagy.
Answer
Calpastatin prevents Angiotensin II-mediated podocyte injury by inhibiting calpain activity. Overexpression of calpastatin in podocytes maintains autophagy flux, thereby protecting podocytes from AngII-induced damage. This suggests that calpastatin could be a potential therapeutic target for preventing podocyte injury in hypertension-associated nephropathies.
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