What are the implications of acute kidney injury (AKI) on the treatment effect of milrinone compared to dobutamine?

Label:chem

Topic
AKI is a frequent complication in cardiogenic shock and can affect drug metabolism and clinical outcomes.
Answer
The study observed an interaction between AKI and the treatment effect of milrinone compared to dobutamine. Patients without AKI treated with milrinone had a lower risk of primary outcomes and death compared to those treated with dobutamine. In contrast, patients with AKI did not show a significant difference in outcomes between milrinone and dobutamine treatment.
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