How does Angiotensin II (AngII) affect podocyte autophagy in hypertension-induced kidney injury?

Label:chem

Topic
Angiotensin II (AngII) is a peptide hormone that plays a key role in the renin-angiotensin system (RAS), which regulates blood pressure and fluid balance. In the context of hypertension, AngII is known to contribute to kidney injury by promoting podocyte injury and glomerulosclerosis. Podocytes are specialized cells in the kidney glomeruli that are crucial for maintaining the glomerular filtration barrier.
Answer
Angiotensin II (AngII) inhibits autophagy flux in podocytes, leading to podocyte injury and glomerulosclerosis. This effect is mediated through the activation of calpains, calcium-dependent proteases that block autophagy. Inhibition of autophagy by AngII is associated with increased albuminuria and glomerulosclerosis in hypertension-induced kidney injury.
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