How does renal function impact the efficacy of milrinone compared to dobutamine in cardiogenic shock?

Label:chem

Topic
Renal dysfunction is common in patients with cardiogenic shock and can affect drug metabolism and excretion. Milrinone's elimination is highly dependent on renal function, which may influence its efficacy and safety.
Answer
The study found that baseline renal function (eGFR <60 ml/min/1.73m²) did not significantly modulate the treatment effect of milrinone compared to dobutamine. However, the presence of AKI significantly influenced the treatment effect, with milrinone showing a lower risk of primary outcomes and death in patients without AKI compared to those with AKI.
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