How does the deletion of Atg5 in podocytes affect the progression of Angiotensin II-induced kidney injury?

Label:chem

Topic
Atg5 is a gene encoding a protein involved in autophagy. Autophagy is a cellular process that degrades and recycles cellular components and is essential for maintaining cellular homeostasis. In podocytes, autophagy is particularly important for maintaining cell integrity and function.
Answer
Deletion of Atg5 specifically in podocytes accelerates Angiotensin II-induced podocytopathy, resulting in increased albuminuria and glomerulosclerosis. This indicates that autophagy is a key protective mechanism in podocytes against Angiotensin II-mediated injury. Maintaining autophagy through calpastatin overexpression can limit podocyte damage and albuminuria.
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