How does Milrinone potentially contribute to cancer therapy?

Label:chem

Topic
Milrinone is a selective phosphodiesterase-3 (PDE3) inhibitor used clinically for its inotropic and vasodilatory effects in patients with heart failure. By inhibiting PDE3, Milrinone prevents the breakdown of cAMP, resulting in elevated intracellular cAMP levels. This elevation activates protein kinase A (PKA), modulates mitochondrial function, and enhances apoptotic signaling pathways.
Answer
Milrinone may promote apoptosis and reduce tumor growth by increasing cAMP levels. It also has potential anti-inflammatory and anti-angiogenic properties, which could make it a useful adjuvant therapy in oncology. Further research is needed to confirm its efficacy and safety in cancer patients.
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