What is the role of trifluoroacetic acid (TFA) in the synthesis of (-)-halenaquinone?

Label:chem

Topic
Trifluoroacetic acid (TFA) is used in the conversion of compound 12 to compound 13.
Answer
Trifluoroacetic acid (TFA) is used to dehydrate compound 12, resulting in the formation of the enone intermediate (13). This step is necessary to introduce the required double bond in the molecule, facilitating further transformations in the synthesis.
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