What is the role of quizartinib in the treatment of acute myeloid leukemia (AML)?

Label:chem

Topic
Quizartinib is a second-generation, highly potent, and selective type II FLT3 inhibitor developed specifically to target FLT3-ITD mutations, which are present in approximately 25% of AML cases.
Answer
Quizartinib works by binding to the inactive conformation of the FLT3 receptor, preventing autophosphorylation and downstream signaling. This effectively blocks leukemic cell proliferation and induces apoptosis, making it a key targeted therapy for FLT3-ITD-positive AML.
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