What are the most potent benzothiazole derivatives as inhibitors of MAO-A and MAO-B?

Label:chem

Topic
A study investigates the inhibition properties of various benzothiazole derivatives on monoamine oxidase (MAO) enzymes, specifically MAO-A and MAO-B, which are implicated in neurodegenerative and neuropsychiatric disorders.
Answer
The most potent benzothiazole derivative for MAO-A inhibition is 6-((4-nitrobenzyl)oxy)benzo[d]thiazole (1f) with an IC50 value of 0.336 μM. For MAO-B inhibition, the most potent derivatives are 6-((3-chlorobenzyl)oxy)benzo[d]thiazole (1e) and 4-((benzo[d]thiazol-6-yloxy)methyl)benzonitrile (1i), both with IC50 values of 0.0028 μM.
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