How does ziprasidone function as an atypical antipsychotic?

Label:chem

Topic
Ziprasidone is a second-generation antipsychotic approved for the treatment of schizophrenia, bipolar mania, and acute agitation in schizophrenia.
Answer
Ziprasidone functions primarily as a dopamine D2 and serotonin 5-HT2A receptor antagonist, with a uniquely high 5-HT2A/D2 affinity ratio. This profile contributes to its efficacy in treating positive and negative symptoms, mood stabilization, and cognitive enhancement, while minimizing motor side effects and metabolic disturbances.
Return to Home Chemical List
Knowledge you may be interested in
What is the role of tropifexor in treating liver disorders? How does Phortress function as an antitumor agent? What is the mechanism of action of Thioflavin-T in amyloid imaging? How does perospirone function as an atypical antipsychotic? What is the role of dexpramipexole in eosinophilic asthma therapy? How does zopolrestat function as an aldose reductase inhibitor? What is the mechanism of action of ethoxzolamide as a carbonic anhydrase inhibitor? How does saccharin function as a non-nutritive sweetener? What is the role of quizartinib in the treatment of acute myeloid leukemia (AML)? How does pramipexole function as a dopamine agonist in the treatment of Parkinson's disease? What is the mechanism of action of benzothiazole-based DNA gyrase inhibitors? How do benzothiazole–profen hybrid amides function as anti-inflammatory agents? What is the role of sodium hypochlorite pentahydrate (NaOCl·5H2O) in the C3-chlorination of C2-substituted benzo[b]thiophene derivatives? How does the presence of a carbonyl group at the C2-position affect the C3-chlorination reaction of benzo[b]thiophene derivatives? What is the effect of benzofuran on the C3-chlorination reaction when used in place of benzo[b]thiophene? What is the role of N-chlorosuccinimide (NCS) in comparison to sodium hypochlorite in the C3-chlorination of benzo[b]thiophene derivatives? How does the presence of a benzylic alcohol group affect the C3-chlorination reaction of benzo[b]thiophene derivatives? What is the significance of using a TBDMS group in the C3-chlorination of benzo[b]thiophene derivatives? What is the role of TAK-285 in targeting HER2 and EGFR in cancer treatment? What are the pharmacokinetic properties of TAK-285 and its metabolite M-I?