What is the mechanism of action of riluzole in the treatment of amyotrophic lateral sclerosis (ALS)?

Label:chem

Topic
Riluzole is a neuroprotective agent approved for the treatment of ALS, a fatal neurodegenerative condition marked by progressive loss of motor neurons.
Answer
Riluzole acts via multiple mechanisms, including inhibition of presynaptic glutamate release, blockade of voltage-gated sodium channels, and enhanced glutamate reuptake. These actions collectively reduce excitotoxicity, a major contributor to motor neuron damage in ALS.
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