How does zopolrestat function as an aldose reductase inhibitor?

Label:chem

Topic
Zopolrestat is a carboxylic acid-based small molecule developed as an aldose reductase inhibitor for managing diabetic complications.
Answer
Zopolrestat inhibits aldose reductase, a key enzyme in the polyol pathway that becomes overactive under hyperglycemic conditions. By inhibiting this enzyme, zopolrestat normalizes levels of sorbitol, fructose, and myo-inositol in diabetic tissues, reducing oxidative stress and tissue damage.
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