What is the role of tropifexor in treating liver disorders?

Label:chem

Topic
Tropifexor is a potent, selective, non-bile-acid farnesoid X receptor (FXR) agonist developed for treating liver disorders, particularly nonalcoholic steatohepatitis (NASH) and primary biliary cholangitis (PBC).
Answer
Tropifexor activates FXR with high potency, leading to the upregulation of FXR target genes and suppression of enzymes involved in lipid metabolism. This results in reduced hepatic fat fraction and improved liver function, making it a promising candidate for treating NASH and PBC.
Return to Home Chemical List
Knowledge you may be interested in
How does Phortress function as an antitumor agent? What is the mechanism of action of Thioflavin-T in amyloid imaging? How does perospirone function as an atypical antipsychotic? What is the role of dexpramipexole in eosinophilic asthma therapy? How does zopolrestat function as an aldose reductase inhibitor? What is the mechanism of action of ethoxzolamide as a carbonic anhydrase inhibitor? How does saccharin function as a non-nutritive sweetener? What is the role of quizartinib in the treatment of acute myeloid leukemia (AML)? How does pramipexole function as a dopamine agonist in the treatment of Parkinson's disease? What is the mechanism of action of riluzole in the treatment of amyotrophic lateral sclerosis (ALS)? How does ziprasidone function as an atypical antipsychotic? What is the mechanism of action of benzothiazole-based DNA gyrase inhibitors? How do benzothiazole–profen hybrid amides function as anti-inflammatory agents? What is the role of sodium hypochlorite pentahydrate (NaOCl·5H2O) in the C3-chlorination of C2-substituted benzo[b]thiophene derivatives? How does the presence of a carbonyl group at the C2-position affect the C3-chlorination reaction of benzo[b]thiophene derivatives? What is the effect of benzofuran on the C3-chlorination reaction when used in place of benzo[b]thiophene? What is the role of N-chlorosuccinimide (NCS) in comparison to sodium hypochlorite in the C3-chlorination of benzo[b]thiophene derivatives? How does the presence of a benzylic alcohol group affect the C3-chlorination reaction of benzo[b]thiophene derivatives? What is the significance of using a TBDMS group in the C3-chlorination of benzo[b]thiophene derivatives? What is the role of TAK-285 in targeting HER2 and EGFR in cancer treatment?