How does pramipexole function as a dopamine agonist in the treatment of Parkinson's disease?
Label:chem
Topic
Pramipexole is a non-ergoline dopamine agonist primarily used for the treatment of Parkinson's disease and Restless Leg Syndrome (RLS).
Answer
Pramipexole exerts its therapeutic effects by selectively stimulating dopamine D2-like receptors, with a marked preference for D3 receptors. This helps restore dopaminergic function in the striatum, alleviating hallmark symptoms such as tremors, rigidity, and bradykinesia in Parkinson's disease.
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