How does flutemetamol (18F) function as a diagnostic tool for Alzheimer's disease?

Label:chem

Topic
Flutemetamol (18F) is an FDA-approved radiopharmaceutical used in PET imaging to assess β-amyloid plaque density in the brain, a critical pathological feature of Alzheimer's disease.
Answer
Flutemetamol (18F) binds with high specificity and affinity to fibrillar amyloid-β aggregates in the brain. After intravenous administration, it crosses the blood–brain barrier and accumulates in amyloid-positive areas, allowing for in vivo visualization of amyloid burden through PET imaging. This helps differentiate Alzheimer's disease from other forms of cognitive impairment.
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