What is the mechanism of action of benzothiazole-based DNA gyrase inhibitors?

Label:chem

Topic
Benzothiazole-based DNA gyrase inhibitors are being developed to target multidrug-resistant Gram-negative pathogens.
Answer
These inhibitors bind to the ATP-binding pocket of the GyrB subunit of bacterial DNA gyrase, forming key hydrogen bonds and cation–π interactions. This binding prevents DNA gyrase from functioning properly, leading to bacterial cell death, making them effective against multidrug-resistant pathogens like Acinetobacter baumannii and Pseudomonas aeruginosa.
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