How does Phortress function as an antitumor agent?

Label:chem

Topic
Phortress is an experimental antitumor agent designed for selective activity against human-derived breast, ovarian, and renal carcinomas.
Answer
Phortress functions through biotransformation of its active component, 5F 203, by the enzyme CYP1A1. The metabolic activation produces electrophilic intermediates that bind covalently to DNA, causing lethal damage specifically in sensitive tumor cells.
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