What is the mechanism of action of Thioflavin-T in amyloid imaging?

Label:chem

Topic
Thioflavin-T is a benzothiazole-based fluorescent dye used to study amyloid fibril formation associated with neurodegenerative diseases.
Answer
Thioflavin-T binds to β-sheet-rich structures within amyloid fibrils, immobilizing its aromatic rings and restricting intramolecular rotation. This binding enhances fluorescence, correlating with fibril formation, making it a useful tool for real-time in vitro amyloid aggregation assays and plaque visualization in brain tissues.
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