What are the key intermediates formed during the synthesis of 3-aminoindoles?

Label:chem

Topic
The synthesis involves a two-step process with specific intermediates being formed.
Answer
The key intermediates formed during the synthesis are:
Spiro[indole-3,5′-isoxazoles]: These are formed in the first step when indoles react with nitrostyrene in the presence of phosphorous acid.
2-(3-Oxoindolin-2-yl)-2-arylacetonitriles: These are formed from the spiro[indole-3,5′-isoxazoles] upon treatment with a mild acid or base. They serve as the starting material for the second step of the synthesis.
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