What is the role of hydrazine hydrate in the synthesis of unprotected 3-aminoindoles?

Label:chem

Topic
A study describes a novel two-step synthesis method for preparing unprotected 3-aminoindoles using hydrazine hydrate as a key reagent in the second step.
Answer
Hydrazine hydrate acts as a reducing agent and a nucleophile in the second step of the synthesis. It reacts with the intermediate spiro[indole-3,5′-isoxazoles] or 2-(3-oxoindolin-2-yl)-2-arylacetonitriles to form the desired 3-aminoindoles. The reaction involves a microwave-assisted heating process, which facilitates the conversion of the intermediate compounds to the final 3-aminoindoles.
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