Which bacterial species are implicated in gemcitabine resistance through CDD-mediated degradation?

Label:chem

Topic
The oral microbiota has been implicated in contributing to chemoresistance in pancreatic cancer. Specific bacterial species expressing cytidine deaminase (CDD) can degrade gemcitabine, rendering it less effective.
Answer
A study identifies several bacterial species associated with pancreatic ductal adenocarcinoma (PDAC) that can degrade gemcitabine through CDD-mediated mechanisms. These include:
Escherichia coli (expressing CDDL)
Aggregatibacter actinomycetemcomitans (expressing CDDL)
Enterococcus faecalis (expressing CDDS)
Streptococcus mutans (expressing CDDS)
Porphyromonas gingivalis (expressing CDDS)
Fusobacterium nucleatum (lacking CDD)
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