What is the significance of nitrostyrene in the synthesis of 3-aminoindoles?

Label:chem

Topic
Nitrostyrene is used in the first step of the two-step synthesis method described in a study.
Answer
Nitrostyrene acts as a 1,4-dipole in the presence of phosphorous acid, reacting with indoles to form spiro[indole-3,5′-isoxazoles]. This intermediate compound can then be converted to the desired 3-aminoindoles using hydrazine hydrate in the second step. The use of nitrostyrene allows for the formation of a stable intermediate that can be easily transformed into the target 3-aminoindoles.
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