Why are breast cancer cells resistant to the effects of low-dose Calyculin A (Caly A)?

Label:chem

Topic
A study compares the response of breast cancer cell lines (MDA-MB-468, MDA-MB-231, and MCF7) to non-cancerous cell lines under the influence of low-dose Caly A.
Answer
Breast cancer cells are resistant to low-dose Caly A because they likely use different calcium entry pathways compared to fibroblasts. Caly A blocks calcium uptake via non-selective cation channels in fibroblasts, but breast cancer cells may rely on other channels unaffected by Caly A.
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