How does Calyculin A (Caly A) affect cell cycle progression in non-cancerous fibroblasts and epithelial cells?

Label:chem

Topic
A study examines the effects of low concentrations of Caly A on cell proliferation in various cell lines, including human fibroblasts (Hs-68) and epithelial cells (ARPE-19).
Answer
Long-term exposure to 0.3 nM Caly A prevents G1 to S phase progression in Hs-68 fibroblasts and ARPE-19 epithelial cells, indicating cell cycle arrest in these non-cancerous cell lines.
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