What is the dual action of Calyculin A (Caly A)?

Label:chem

Topic
Calyculin A (Caly A) is a toxin isolated from the marine sponge Discodermia calyx, known for its inhibitory effects on protein Ser/Thr phosphatases of the PPP family. This study investigates its effects on cell proliferation and calcium influx.
Answer
Caly A acts as both a channel blocker and a protein phosphatase inhibitor. At subnanomolar doses, it blocks calcium uptake by fibroblasts, preventing G1 to S phase cell cycle progression, while higher doses inhibit protein phosphatases.
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