What is the role of trifluoroacetic acid (TFA) and triethylsilane (TES) in the synthesis of benzyl derivatives 3a and 3b?

Label:chem

Topic
The synthesis of benzyl derivatives 3a and 3b involves the use of TFA and TES.
Answer
TFA is used to deprotect the hydroxyl group in the benzyl alcohol intermediates (2a and 2b), while TES acts as a source of hydride ions to reduce the carbonyl group, resulting in the formation of the benzyl derivatives 3a and 3b in high purity and yield (98% for both compounds).
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