Does the cell extract of VH Akkermansia muciniphila induce GLP-1 secretion from human NCI-H716 L-cells, and how potent is this induction?

Label:chem

Topic
GLP-1, secreted by intestinal L-cells, is a key incretin hormone; the authors evaluated the extract’s ability to trigger GLP-1 release from the NCI-H716 human L-cell line.
Answer
The extract produces a robust, dose- and time-dependent rise in GLP-1 secretion, achieving >2000 % increase (from ~3 pM baseline to ~90 pM) at 500 µg/mL after 60 min, a level comparable to the positive control 10 mM glutamine (≈116 pM).
Return to Home Chemical List
Knowledge you may be interested in
Does the cell extract of VH Akkermansia muciniphila stimulate insulin secretion from INS-1 pancreatic β-cells, and how strong is this effect compared with glucose stimulation? Does matcha powder (whole-leaf green tea) produce stronger metabolic effects than standard green-tea infusions? How does EGCG affect lipid metabolism and hepatic steatosis in animal models of diet-induced MAFLD? What is the established safe daily intake range for epigallocatechin-3-gallate (EGCG) from tea infusions? What are the principal bioactive compounds in matcha and green tea that are believed to influence liver metabolism and steatosis? What are the carcinogenic and non-carcinogenic health risks of acrylamide exposure in adolescents? What is acrylamide and how does it form in foods? What is the optimal preload timing for isomaltulose (ISO) to enhance the second meal effect (SME)? How does isomaltulose (ISO) affect incretin hormone release compared to saccharose (SUC)? What is isomaltulose (ISO) and how does it differ from saccharose (SUC) in terms of chemical structure and glycemic index? Which bioactive components of Akkermansia muciniphila are implicated in GLP-1 induction? How does Akkermansia muciniphila improve metabolic health beyond direct hormone secretion? What is curcumin and where is it sourced from? What is the association between curcumin-rich curry consumption and cognitive decline? What mechanisms explain curcumin’s neuroprotective effects? What is the chemical identity and basic function of selenium in human physiology? How does selenium exert its antioxidant action at the molecular level? Which selenoproteins are up-regulated or down-regulated in MASLD and what are the functional consequences? How do probiotics reduce uric acid levels in humans? What factors were identified as moderators of the probiotic effect on uric acid levels?