Which selenoproteins are up-regulated or down-regulated in MASLD and what are the functional consequences?

Label:chem

Topic
Transcriptomic and experimental data from rodent and porcine models are summarized.
Answer
GPX1, GPX4, TXNRD1, SELENOS, and SELENOM expression fall under selenium deficiency, leading to redox imbalance, NF-κB activation, inflammation, and fibrosis.
SELENOP and SELENOK are paradoxically linked to insulin resistance and hepatic steatosis; high SELENOP impairs insulin receptor/Akt signaling, whereas SELENOK promotes CD36-mediated fatty-acid uptake.
SELENOW up-regulation correlates with hepatocyte apoptosis and pyroptosis.
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